Tag Archives: genetics

Autism – nature PLUS nurture?

‘A new study is offering a clue into the origins of the disorder by finding a single dysfunctional protein may be responsible for coordinating expression in all the genes that result in autism susceptibility.’

I took that quote from an article on autism research published by New Atlas. I strongly recommend reading the entire article but the gist is that:

  1. Researchers have found hundreds of genes implicated in the Autism Disorder spectrum, not just one ‘master’ gene.
  2. These genes are like switches that can be turned on or off.
  3. While these genes are ‘off’, the person may have a tendency towards autism, but they will not be autistic – i.e. there will be no symptoms of autism.
  4. There is a protein called CPEB4 which ‘…is vital in embryonic development, assisting with neuroplasticity and helping regulate the expression of certain genes during fetal brain development.’ In other words, this is a good protein.
  5. In mouse models, not enough of this protein leads to brain structures and behaviours that are characteristic of autism. In other words, the lack of this protein causes those autism-related genes to be switched on and the result is Autism-like behaviour.

Now, mouse models are just an approximation of the human condition, but they do lend support to the idea that autism is not just a genetic condition/disorder. Instead, it may well be a case of environment acting on an underlying pre-disposition. And if that is the case, then maybe one day we’ll be able to keep those Autism related genes switched off.

Have a great weekend,

Meeks

 


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